Since the emergence of positive psychology, there has been a renewed interest in understanding the protective psychological factors that help people to prevent the onset of psychological maladjustment and problem behaviors and increase their well-being. One of the most active contexts to work on the promotion of well-being is the field of digitalization. In this sense, this symposium aims to present different lines of research in the field of positive personal resources, and how these resources help to predict and explain different indicators of well-being, health and interpersonal functioning. Through the different papers, emphasis is placed on the explanatory mechanisms that help to predict well-being and the potential benefits of carrying out prevention programs in intervention in these personal resources to improve well-being and health levels are highlighted.